Innovation
Our portfolio
We are leading a revolutionary change in the treatment of more than 10 cancers and demonstrated, in clinical trials, the survival benefits of our immunotherapies in patients with metastatic disease as well as earlier stages of cancer as adjuvant therapy, when the immune system may be more intact and potentially more responsive to treatment. By combining our immunotherapies with other medicines, as well as chemotherapies, we continue to improve response rates for certain patients.
We are progressing cell therapies from pipeline to certain patients and are the only company with two approved cell therapies directed against two distinct targets. Building on this, we continue to invest in technology and manufacturing methods, using novel constructs to make CAR T cells more consistent and persistent in our pursuit of the next treatment frontiers. Leveraging one of the largest datasets of CAR T translational and clinical data in the industry, we’re also evaluating a broad portfolio of cell therapy treatments across earlier lines of therapy, in purposeful pursuit of better patient outcomes.
Today, our Immunology franchise encompasses two marketed products and a robust pipeline of more than 20 programs across nearly 20 diseases. As we continuously build and expand our portfolio, our teams work to identify mechanisms that may help the body control inflammation, reset the immune system and promote balance in immune response: a three-point approach with the goal of achieving long-term remission and, ultimately, curative therapies.
With three promising late-stage assets across ulcerative colitis, Crohn’s disease and eosinophilic esophagitis, each with a unique mechanism of action, we are making progress in our efforts to develop and deliver novel treatment options. From oral treatments to biologics and combination therapies, these innovations have the potential to provide patients with relief that may empower them to take back what these diseases often take away.
Through our continued investments in research, we are continuing to expand our pipeline of treatments that harness the power of the body’s own immune system to treat cancers. Advances in genetic engineering enable us to create T cells that target specific proteins in cancer cells, enlisting the body’s natural immune system in the defeat of cancer. We have seen similar extraordinary gains in the prognosis of patients with multiple myeloma, the blood cancer that is treated by Revlimid.
Experts estimate that this year, more than 32,000 Americans will be diagnosed with new cases of multiple myeloma, and more than 12,000 people will die from this devastating disease. Nonetheless, the prognosis for a multiple myeloma patient today is far better than it was just a few years ago. The advances in multiple myeloma treatments are especially noteworthy when compared to other cancers: the five-year survival rate for multiple myeloma increased four times faster than for other cancers.
Bristol Myers Squibb has a strong record of devoting substantial portions of our overall revenue to research and development. Prior to its acquisition by BMS in 2019, Celgene did, too. According to the 2019 EU Industrial Research and Development Scoreboard, which ranks the top companies in the world by R&D spending, of the 50 companies globally with the most R&D spending in any industry, Celgene was ranked first, and Bristol Myers Squibb was ranked second for R&D spending as a share of revenue. As a combined company in 2020, we invested $11.1 billion in research and development.
| Phase I | Phase II | Phase III | Marketed | |
|---|---|---|---|---|
| Oncology |
Phase I
|
Phase II
|
Phase III
|
Marketed
|
| Hematology |
Phase I
|
Phase II
|
Marketed  |
|
| Cardiovascular |
Phase I
|
Phase II
|
Phase III
|
Marketed  |
| Immunology |
Phase I
|
Phase II
|
Phase III
|
Marketed  |
| Fibrosis |
Phase I
|
Phase II
|
||
| Neuroscience |
Phase I
|
|||
| COVID-19 |
Phase I
|
*In development for solid tumors and hematology.
**BMS has an exclusive option to license and/or option to acquire.
